DrugRepV Browse Page


DrugRepV browse page allows user to take a glance of the particular antiviral agent.Fields in the webpage is hylerlinked ot various external repositories like DrugBank, PubChem, Clinicaltrials.gov,and PubMed.User can explore the biological, Clinical, Chemical, and Structural details of every repurposed drug candidate.By clicking on the table header arrows, user can sort entries in ascending or descending order.


Total number of Records for MTT assay are 379




DrugRepV_ID Antiviral Name
Drug type
Primary Indication
Secondary Indication
Strain
Pathways
Assay
Activity
Clinical Status
References
DrugRepV_1910Amodiaquine
Antiparasitic products, Insectisides and Repellents
Malaria
Zika virus
PLCal_ZV
NA
MTT assay
Decrease (50 %)
Approved
29315671
DrugRepV_1911Chloroquine
Antiparasitic products, Insectisides and Repellents
Malaria
Zika virus
PLCal_ZV
NA
MTT assay
Decrease (50 %)
Approved
29315671
DrugRepV_1912Mycophenolic Acid
Antineoplastic and Immunomodulating Agents
Organ rejection (immunosuppressants)
Zika virus
PLCal_ZV
NA
MTT assay
Decrease (50 %)
Approved
29315671
DrugRepV_1922Amodiaquine
Antiparasitic products, Insectisides and Repellents
Malaria
Zika virus
PLCal_ZV
NA
MTT assay
Decrease (65 %)
Approved
29315671
DrugRepV_1923Chloroquine
Antiparasitic products, Insectisides and Repellents
Malaria
Zika virus
PLCal_ZV
NA
MTT assay
Decrease (70 %)
Approved
29315671
DrugRepV_1924Mycophenolic Acid
Antineoplastic and Immunomodulating Agents
Organ rejection (immunosuppressants)
Zika virus
PLCal_ZV
NA
MTT assay
Decrease (62.5 %)
Approved
29315671
DrugRepV_2974Doxycycline
Antiinfectives For Systemic Use
Bacterial infections
Chikungunya virus
Clinical isolate of CHIKV (East/Central/South African genotype)
NA
MTT assay
Decrease (65 %)
Approved
25970853
DrugRepV_2975Ribavirin
Antiinfectives For Systemic Use
Hepatitis C virus
Chikungunya virus
Clinical isolate of CHIKV (East/Central/South African genotype)
NA
MTT assay
Decrease (71.6 %)
Approved
25970853
DrugRepV_2976Doxycycline-Ribavirin
NA
NA
Chikungunya virus
Clinical isolate of CHIKV (East/Central/South African genotype)
NA
MTT assay
Decrease (88.2 %)
Approved
25970853
DrugRepV_3323Naproxen
Musculo-Skeletal System
Rheumatoid arthritis | Osteoarthritis | Ankylosing spondylitis | Polyarticular juvenile idiopathic arthritis | Tendinitis | Bursitis | Acute gout | Primary dysmenorrhea
Influenza virus
A/WSN/33
Pathway
MTT assay
Decrease (50 %)
Approved
23459490
DrugRepV_3864Favipiravir
Antiviral
Influenza virus
Crimean-Congo hemorrhagic fever virus
Afg-09 2990
NA
MTT assay
Decrease (50 %)
Investigational
27736754
DrugRepV_3865Favipiravir
Antiviral
Influenza virus
Ebola virus
Mayinga 1976
NA
MTT assay
Decrease (50 %)
Investigational
27736754
DrugRepV_41841-(4-{2-[1-cyclohexyl-2-(furan-3-yl)-1H-1,3-benzodiazol-5-yl]-1,3-oxazol-5-yl}phenyl)pyrrolidin-2-one
NA
NA
Chikungunya virus
SL10571
NA
MTT assay
Decrease (50 %)
NA
28236746
DrugRepV_4185Favipiravir
Antiviral
Influenza virus
Chikungunya virus
SL10571
NA
MTT assay
Decrease (50 %)
Investigational
28236746
DrugRepV_41861-(4-{2-[1-cyclohexyl-2-(furan-3-yl)-1H-1,3-benzodiazol-5-yl]-1,3-oxazol-5-yl}phenyl)pyrrolidin-2-one
NA
NA
Chikungunya virus
S27
NA
MTT assay
Decrease (50 %)
NA
28236746
DrugRepV_4187Favipiravir
Antiviral
Influenza virus
Chikungunya virus
S27
NA
MTT assay
Decrease (50 %)
Investigational
28236746
DrugRepV_41881-(4-{2-[1-cyclohexyl-2-(furan-3-yl)-1H-1,3-benzodiazol-5-yl]-1,3-oxazol-5-yl}phenyl)pyrrolidin-2-one
NA
NA
Chikungunya virus
BaH306
NA
MTT assay
Decrease (50 %)
NA
28236746
DrugRepV_4189Favipiravir
Antiviral
Influenza virus
Chikungunya virus
BaH306
NA
MTT assay
Decrease (50 %)
Investigational
28236746
DrugRepV_4302Carbocyclic adenosine
NA
NA
Ebola virus
Mayinga
NA
MTT assay
Decrease (50 %)
NA
9988190
DrugRepV_4303Carbocyclic 3-deazaadenosine
NA
NA
Ebola virus
Mayinga
NA
MTT assay
Decrease (50 %)
NA
9988190
DrugRepV_43049-[trans- 2,trans - 3 - dihydroxy - 4 - (methyl) - cyclopent - 4 - enyl] - 3 - deazaadenine
NA
NA
Ebola virus
Mayinga
NA
MTT assay
Decrease (50 %)
NA
9988190
DrugRepV_43059-[trans-2,trans-3-dihydroxy-4-hydroxymethyl-cyclopent-4-enyl]-adenine
NA
NA
Ebola virus
Mayinga
NA
MTT assay
Decrease (50 %)
NA
9988190
DrugRepV_43069-[trans-2,trans-3-dihydroxy-4-hydroxymethyl-cyclopent-4-enyl]-3-deazaadenine
NA
NA
Ebola virus
Mayinga
NA
MTT assay
Decrease (50 %)
NA
9988190
DrugRepV_43079-[trans-2,trans-3-dihydroxycyclopent-4-enyl]- adenine (DHCpAdo)
NA
NA
Ebola virus
Mayinga
NA
MTT assay
Decrease (50 %)
NA
9988190
DrugRepV_43089-[trans-2,trans-3-dihydroxycyclopent- 4-enyl]-3-deazaadenine (DHCp-c3Ado)
NA
NA
Ebola virus
Mayinga
NA
MTT assay
Decrease (50 %)
NA
9988190
DrugRepV_43094,5- didehydro-5-deoxy-5-fluoroadenosine (DDFA)
NA
NA
Ebola virus
Mayinga
NA
MTT assay
Decrease (50 %)
NA
9988190
DrugRepV_4310Ribavirin
Antiinfectives For Systemic Use
Hepatitis C virus
Ebola virus
Mayinga
NA
MTT assay
Decrease (50 %)
Approved
9988190
DrugRepV_4311Guanosine Dialdehyde
NA
NA
Ebola virus
Mayinga
NA
MTT assay
Decrease (50 %)
NA
9988190
DrugRepV_4312Adenosine Dialdehyde
NA
NA
Ebola virus
Mayinga
NA
MTT assay
Decrease (50 %)
Approved, Investigational
9988190
DrugRepV_5409Chloroquine
Antiparasitic products, Insectisides and Repellents
Malaria
Zika virus
PLCal_ZV
NA
MTT assay
Decrease (50 %)
Approved
30801742
DrugRepV_5410Desethylamodiaquine
NA
NA
Zika virus
PLCal_ZV
NA
MTT assay
Decrease (50 %)
NA
30801742
DrugRepV_5411Desethylchloroquine
NA
NA
Zika virus
PLCal_ZV
NA
MTT assay
Decrease (50 %)
NA
30801742
DrugRepV_5412Chloroquine
Antiparasitic products, Insectisides and Repellents
Malaria
Zika virus
MR 766
NA
MTT assay
Decrease (50 %)
Approved
30801742
DrugRepV_5413Desethylamodiaquine
NA
NA
Zika virus
MR 766
NA
MTT assay
Decrease (50 %)
NA
30801742
DrugRepV_5414Desethylchloroquine
NA
NA
Zika virus
MR 766
NA
MTT assay
Decrease (50 %)
NA
30801742
DrugRepV_5415Chloroquine
Antiparasitic products, Insectisides and Repellents
Malaria
Zika virus
PRVABC59
NA
MTT assay
Decrease (50 %)
Approved
30801742
DrugRepV_5416Desethylamodiaquine
NA
NA
Zika virus
PRVABC59
NA
MTT assay
Decrease (50 %)
NA
30801742
DrugRepV_5417Desethylchloroquine
NA
NA
Zika virus
PRVABC59
NA
MTT assay
Decrease (50 %)
NA
30801742
DrugRepV_5484Chlorcyclizine
Respiratory System
Allergic rhinitis
Zika virus
NA
NA
MTT assay
Decrease (50 %)
Approved
31850756
DrugRepV_60384-(5-(4-Fluorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Dengue virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_60394-(5-(2-chlorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Dengue virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_60404-(5-(3-chlorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Dengue virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_60414-(3-Phenyl-5-(o-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Dengue virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_60424-(3-Phenyl-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Dengue virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_60434-(3-(4-phenoxyphenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Dengue virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_60444-(5-(2-fluorophenyl)-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Dengue virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_60454-(5-(3-fluorophenyl)-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Dengue virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_60464-(5-(4-fluorophenyl)-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Dengue virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_60474-(5-(2-chlorophenyl)-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Dengue virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_60484-(5-(3-chlorophenyl)-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Dengue virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_60494-(5-(4-chlorophenyl)-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Dengue virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_60504-(3-(4-phenoxyphenyl)-5-(o-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Dengue virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_60514-(3-(4-phenoxyphenyl)-5-(m-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Dengue virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_60524-(3-(4-phenoxyphenyl)-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Dengue virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_60534-(3-(4-(benzyloxy)phenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Dengue virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_60544-(3-(4-(benzyloxy)phenyl)-5-(2-fluorophenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Dengue virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_60554-(3-(4-(benzyloxy)phenyl)-5-(3-fluorophenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Dengue virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_60564-(3-(4-(benzyloxy)phenyl)-5-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Dengue virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_60574-(3-(4-(benzyloxy)phenyl)-5-(2-chlorophenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Dengue virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_60584-(3-(4-(benzyloxy)phenyl)-5-(3-chlorophenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Dengue virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_60594-(3-(4-(benzyloxy)phenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Dengue virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_60604-(3-(4-(benzyloxy)phenyl)-5-(o-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Dengue virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_60614-(3-(4-(benzyloxy)phenyl)-5-(m-tolyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Dengue virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_60624-(3-(4-(benzyloxy)phenyl)-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Dengue virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_6101CM-10-18
NA
NA
Dengue virus
New Guinea C
Pathway
MTT assay
Decrease (50 %)
NA
23578725
DrugRepV_6102IHVR11029
NA
NA
Dengue virus
New Guinea C
Pathway
MTT assay
Decrease (50 %)
NA
23578725
DrugRepV_6103IHVR17028
NA
NA
Dengue virus
New Guinea C
Pathway
MTT assay
Decrease (50 %)
NA
23578725
DrugRepV_6104IHVR19029
NA
NA
Dengue virus
New Guinea C
Pathway
MTT assay
Decrease (50 %)
NA
23578725
DrugRepV_6115Favipiravir
Antiviral
Influenza virus
Dengue virus
hu/PHL/10-07
Pathway
MTT assay
Decrease (50 %)
Investigational
28236746
DrugRepV_6116Favipiravir
Antiviral
Influenza virus
Dengue virus
hu/INDIA/09–74
Pathway
MTT assay
Decrease (50 %)
Investigational
28236746
DrugRepV_6124Tomatidine
NA
NA
Dengue virus
16681
Pathway
MTT assay
Decrease (50 %)
NA
30468746
DrugRepV_6125Tomatidine
NA
NA
Dengue virus
16007
Pathway
MTT assay
Decrease (50 %)
NA
30468746
DrugRepV_6126Tomatidine
NA
NA
Dengue virus
H87
Pathway
MTT assay
Decrease (50 %)
NA
30468746
DrugRepV_6127Tomatidine
NA
NA
Dengue virus
1036
Pathway
MTT assay
Decrease (50 %)
NA
30468746
DrugRepV_6158Mycophenolic Acid
Antineoplastic and Immunomodulating Agents
Organ rejection (immunosuppressants)
Dengue virus
16681
Pathway
MTT assay
Decrease (50 %)
Approved
22068705
DrugRepV_6159Ribavirin
Antiinfectives For Systemic Use
Hepatitis C virus
Dengue virus
16681
Pathway
MTT assay
Decrease (50 %)
Approved
22068705
DrugRepV_61605hydroxyl-6,7,3,4,5-pentamethoxyflavone
NA
NA
Dengue virus
16681
Pathway
MTT assay
Decrease (50 %)
NA
22068705
DrugRepV_61615,3-dihydroxy-6,7,4,5-tetramethoxyflavone
NA
NA
Dengue virus
16681
Pathway
MTT assay
Decrease (50 %)
NA
22068705
DrugRepV_6162BZ-TRP-TSC
NA
NA
Dengue virus
NA
Pathway
MTT assay
Decrease (85 %)
NA
27490721
DrugRepV_6163BZ-TRP-TSC
NA
NA
Dengue virus
NA
Pathway
MTT assay
Decrease (76 %)
NA
27490721
DrugRepV_6164BZ-TRP-TSC
NA
NA
Dengue virus
NA
Pathway
MTT assay
Decrease (65 %)
NA
27490721
DrugRepV_6165BZ-TRP-TSC
NA
NA
Dengue virus
NA
Pathway
MTT assay
Decrease (76 %)
NA
27490721
DrugRepV_68674-(3,5-Diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68684-(5-(2-Fluorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68694-(5-(3-fluorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68704-(5-(4-Fluorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68714-(5-(2-chlorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68724-(5-(3-chlorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68734-(5-(4-chlorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68744-(3-Phenyl-5-(o-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68754-(3-Phenyl-5-(m-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68764-(3-Phenyl-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68774-(3-(4-phenoxyphenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68784-(5-(2-fluorophenyl)-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68794-(5-(3-fluorophenyl)-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68804-(5-(4-fluorophenyl)-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68814-(5-(2-chlorophenyl)-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68824-(5-(3-chlorophenyl)-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68834-(5-(4-chlorophenyl)-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68844-(3-(4-phenoxyphenyl)-5-(o-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68854-(3-(4-phenoxyphenyl)-5-(m-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68864-(3-(4-phenoxyphenyl)-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68874-(3-(4-(benzyloxy)phenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68884-(3-(4-(benzyloxy)phenyl)-5-(2-fluorophenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68894-(3-(4-(benzyloxy)phenyl)-5-(3-fluorophenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68904-(3-(4-(benzyloxy)phenyl)-5-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68914-(3-(4-(benzyloxy)phenyl)-5-(2-chlorophenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68924-(3-(4-(benzyloxy)phenyl)-5-(3-chlorophenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68934-(3-(4-(benzyloxy)phenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68944-(3-(4-(benzyloxy)phenyl)-5-(o-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68954-(3-(4-(benzyloxy)phenyl)-5-(m-tolyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_68964-(3-(4-(benzyloxy)phenyl)-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Human immunodeficiency virus
NA
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_6897Phorbol
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6898Phorbol-12-acetate
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6899Phorbol-12-decanoate
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6900Phorbol-13-acetate
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6901Phorbol-13-butyrate
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6902Phorbol-13-decanoate
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6903Phorbol-13-tetradecanoate
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6904Phorbol-12,13-diacetate
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6905Phorbol-12,13-dibutyrate
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6906Phorbol-12,13- dihexanoate
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6907Phorbol-12,13-didecanoate
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_69084α-phorbol-12,13-didecanoate
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_690912-O-tetradecanoylphorbol-13-acetate
NA
Cancer
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
Phase II
25970561
DrugRepV_691012-O-tetradecanoyl-4γ-phorbol-13-acetate
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_691112-O- tiglylphorbol-13-decanoate
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_691212-O-(N-methylanthranilate) phorbol-13-acetate
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6913Phorbol-13,20-diacetate
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_691412,13-O,O-dinonanoylphorbol-20-homovanillate
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_691512-O-phenylacetyl-13-O-acetylphorbol-20-homovanillate
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6916Phorbol-12,13,20-triacetate
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_691720-oxo-20-deoxyphorbol-12,13-dibutyrate
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_691812-O-tetradecanoyl-20-oxo-20-deoxyphorbol-13-acetate
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_691912-deoxyphorbol-13-acetate
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_692013-O-isobutyryl-12-deoxyphorbol-20-acetate
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_692113-O-phenylacetyl-12-deoxyphorbol-20-acetate
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6922Ingenol
Dermatologicals
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6923Ingenol-3-mebutate
Dermatologicals
Actinic keratosis
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
Approved
25970561
DrugRepV_6924Ingenol-3,20-dibenzoate
Dermatologicals
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6925Resiniferatoxin
NA
Interstitial cystitis and urinary incontinence
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
Investigational
25970561
DrugRepV_6926AzidoThymidine
Antiinfectives For Systemic Use
Acquired immunodeficiency syndrome
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
Approved
25970561
DrugRepV_6927Phorbol
NA
NA
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6928Phorbol-12-acetate
NA
NA
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6929Phorbol-12-decanoate
NA
NA
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6930Phorbol-13-acetate
NA
NA
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6931Phorbol-13-butyrate
NA
NA
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6932Pphorbol-13-decanoate
NA
NA
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6933Phorbol-13-tetradecanoate
NA
NA
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6934Phorbol-12,13-diacetate
NA
NA
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6935Phorbol-12,13-dibutyrate
NA
NA
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6936Phorbol-12,13- dihexanoate
NA
NA
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6937Phorbol-12,13-didecanoate
NA
NA
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_69384α-phorbol-12,13-didecanoate
NA
NA
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_693912-O-tetradecanoylphorbol-13-acetate
NA
Cancer
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
Phase II
25970561
DrugRepV_694012-O-tetradecanoyl-4?-phorbol-13-acetate
NA
NA
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_694112-O- tiglylphorbol-13-decanoate
NA
NA
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_694212-O-(N-methylanthranilate) phorbol-13-acetate
NA
NA
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6943Phorbol-13,20-diacetate
NA
NA
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_694412,13-O,O-dinonanoylphorbol-20-homovanillate
NA
NA
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_694512-O-phenylacetyl-13-O-acetylphorbol-20-homovanillate
NA
NA
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6946Phorbol-12,13,20-triacetate
NA
NA
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_694720-oxo-20-deoxyphorbol-12,13-dibutyrate
NA
NA
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_694812-O-tetradecanoyl-20-oxo-20-deoxyphorbol-13-acetate
NA
NA
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_694912-deoxyphorbol-13-acetate
NA
NA
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_695013-O-isobutyryl-12-deoxyphorbol-20-acetate
NA
NA
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_695113-O-phenylacetyl-12-deoxyphorbol-20-acetate
NA
NA
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6952Ingenol
Dermatologicals
NA
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6953Ingenol-3-mebutate
Dermatologicals
Actinic keratosis
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
Approved
25970561
DrugRepV_6954Ingenol-3,20-dibenzoate
Dermatologicals
NA
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
NA
25970561
DrugRepV_6955Resiniferatoxin
NA
Interstitial cystitis and urinary incontinence
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
Investigational
25970561
DrugRepV_6956AzidoThymidine
Antiinfectives For Systemic Use
Acquired immunodeficiency syndrome
Human immunodeficiency virus
ROD
Pathway
MTT assay
Decrease (50 %)
Approved
25970561
DrugRepV_71154-(3,5-Diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71164-(5-(2-Fluorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71174-(5-(3-fluorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71184-(5-(4-Fluorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71194-(5-(2-chlorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71204-(5-(3-chlorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71214-(5-(4-chlorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71224-(3-Phenyl-5-(o-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71234-(3-Phenyl-5-(m-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71244-(3-Phenyl-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71254-(3-(4-phenoxyphenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71264-(5-(2-fluorophenyl)-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71274-(5-(3-fluorophenyl)-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71284-(5-(4-fluorophenyl)-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71294-(5-(2-chlorophenyl)-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71304-(5-(3-chlorophenyl)-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71314-(5-(4-chlorophenyl)-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71324-(3-(4-phenoxyphenyl)-5-(o-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71334-(3-(4-phenoxyphenyl)-5-(m-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71344-(3-(4-phenoxyphenyl)-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71354-(3-(4-(benzyloxy)phenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71364-(3-(4-(benzyloxy)phenyl)-5-(2-fluorophenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71374-(3-(4-(benzyloxy)phenyl)-5-(3-fluorophenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71384-(3-(4-(benzyloxy)phenyl)-5-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71394-(3-(4-(benzyloxy)phenyl)-5-(2-chlorophenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71404-(3-(4-(benzyloxy)phenyl)-5-(3-chlorophenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71414-(3-(4-(benzyloxy)phenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71424-(3-(4-(benzyloxy)phenyl)-5-(o-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71434-(3-(4-(benzyloxy)phenyl)-5-(m-tolyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71444-(3-(4-(benzyloxy)phenyl)-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
Yellow fever virus
17D
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71454-(5-(4-Fluorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
West Nile virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71464-(5-(2-chlorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
West Nile virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71474-(5-(3-chlorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
West Nile virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71484-(3-Phenyl-5-(o-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
West Nile virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71494-(3-Phenyl-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
West Nile virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71504-(3-(4-phenoxyphenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
West Nile virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71514-(5-(2-fluorophenyl)-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
West Nile virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71524-(5-(3-fluorophenyl)-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
West Nile virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71534-(5-(4-fluorophenyl)-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
West Nile virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71544-(5-(2-chlorophenyl)-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
West Nile virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71554-(5-(3-chlorophenyl)-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
West Nile virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71564-(5-(4-chlorophenyl)-3-(4-phenoxyphenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
West Nile virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71574-(3-(4-phenoxyphenyl)-5-(o-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
West Nile virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71584-(3-(4-phenoxyphenyl)-5-(m-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
West Nile virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71594-(3-(4-phenoxyphenyl)-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
West Nile virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71604-(3-(4-(benzyloxy)phenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
West Nile virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71614-(3-(4-(benzyloxy)phenyl)-5-(2-fluorophenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
West Nile virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71624-(3-(4-(benzyloxy)phenyl)-5-(3-fluorophenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
West Nile virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71634-(3-(4-(benzyloxy)phenyl)-5-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
West Nile virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71644-(3-(4-(benzyloxy)phenyl)-5-(2-chlorophenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
West Nile virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71654-(3-(4-(benzyloxy)phenyl)-5-(3-chlorophenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
West Nile virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71664-(3-(4-(benzyloxy)phenyl)-5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
West Nile virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71674-(3-(4-(benzyloxy)phenyl)-5-(o-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
NA
NA
West Nile virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71684-(3-(4-(benzyloxy)phenyl)-5-(m-tolyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
West Nile virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_71694-(3-(4-(benzyloxy)phenyl)-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-1- yl)benzenesulfonamide
NA
NA
West Nile virus
Clinical isolate
Pathway
MTT assay
Decrease (50 %)
NA
29028528
DrugRepV_7908Antimycin A
NA
NA
Influenza virus
A/Puerto Rico/8/34
Pathway
MTT assay
Decrease (50 %)
NA
31941776
DrugRepV_7909Brequinar
NA
NA
Influenza virus
A/Puerto Rico/8/34
Pathway
MTT assay
Decrease (50 %)
Experimental
31941776
DrugRepV_79106-Azauridine
NA
Cancer
Influenza virus
A/Puerto Rico/8/34
Pathway
MTT assay
Decrease (50 %)
NA
31941776
DrugRepV_7911Azaribine
NA
Psoriasis
Influenza virus
A/Puerto Rico/8/34
Pathway
MTT assay
Decrease (50 %)
NA
31941776
DrugRepV_7912Pyrazofurin
NA
NA
Influenza virus
A/Puerto Rico/8/34
Pathway
MTT assay
Decrease (50 %)
NA
31941776
DrugRepV_7913AVN-944
NA
Cancer
Influenza virus
A/Puerto Rico/8/34
Pathway
MTT assay
Decrease (50 %)
Investigational
31941776
DrugRepV_7914Mycophenolate mofetil
NA
Organ rejection (immunosuppressants)
Influenza virus
A/Puerto Rico/8/34
Pathway
MTT assay
Decrease (50 %)
Approved, Investigational
31941776
DrugRepV_7915Mycophenolic acid
Antineoplastic and Immunomodulating Agents
Organ rejection (immunosuppressants)
Influenza virus
A/Puerto Rico/8/34
Pathway
MTT assay
Decrease (50 %)
Approved
31941776
DrugRepV_7916Obatoclax
Anticancer
Leukemia | Myelofibrosis | Hodgkin's Lymphoma | Mantle-Cell Lymphoma
Influenza virus
A/Puerto Rico/8/34
Pathway
MTT assay
Decrease (50 %)
Investigational
31941776
DrugRepV_7917OSU-03012
Anticancer
Brain cancer
Influenza virus
A/Puerto Rico/8/34
Pathway
MTT assay
Decrease (50 %)
NA
31941776
DrugRepV_7918Antimycin A
NA
NA
Influenza virus
B/Brisbane/60/08
Pathway
MTT assay
Decrease (50 %)
NA
31941776
DrugRepV_7919Brequinar
NA
NA
Influenza virus
B/Brisbane/60/08
Pathway
MTT assay
Decrease (50 %)
Experimental
31941776
DrugRepV_79206-Azauridine
NA
Cancer
Influenza virus
B/Brisbane/60/08
Pathway
MTT assay
Decrease (50 %)
NA
31941776
DrugRepV_7921Azaribine
NA
Psoriasis
Influenza virus
B/Brisbane/60/08
Pathway
MTT assay
Decrease (50 %)
NA
31941776
DrugRepV_7922Pyrazofurin
NA
NA
Influenza virus
B/Brisbane/60/08
Pathway
MTT assay
Decrease (50 %)
NA
31941776
DrugRepV_7923AVN-944
NA
Cancer
Influenza virus
B/Brisbane/60/08
Pathway
MTT assay
Decrease (50 %)
Investigational
31941776
DrugRepV_7924Mycophenolate mofetil
NA
Organ rejection (immunosuppressants)
Influenza virus
B/Brisbane/60/08
Pathway
MTT assay
Decrease (50 %)
Approved, Investigational
31941776
DrugRepV_7925Mycophenolic acid
Antineoplastic and Immunomodulating Agents
Organ rejection (immunosuppressants)
Influenza virus
B/Brisbane/60/08
Pathway
MTT assay
Decrease (50 %)
Approved
31941776
DrugRepV_7926Antimycin A
NA
NA
Influenza virus
A/Puerto Rico/8/34
Pathway
MTT assay
Decrease (50 %)
NA
31941776
DrugRepV_7927Brequinar
NA
NA
Influenza virus
A/Puerto Rico/8/34
Pathway
MTT assay
Decrease (50 %)
Experimental
31941776
DrugRepV_79286-Azauridine
NA
Cancer
Influenza virus
A/Puerto Rico/8/34
Pathway
MTT assay
Decrease (50 %)
NA
31941776
DrugRepV_7929Azaribine
NA
Psoriasis
Influenza virus
A/Puerto Rico/8/34
Pathway
MTT assay
Decrease (50 %)
NA
31941776
DrugRepV_7930Pyrazofurin
NA
NA
Influenza virus
A/Puerto Rico/8/34
Pathway
MTT assay
Decrease (50 %)
NA
31941776
DrugRepV_7931AVN-944
NA
Cancer
Influenza virus
A/Puerto Rico/8/34
Pathway
MTT assay
Decrease (50 %)
Investigational
31941776
DrugRepV_7932Mycophenolate mofetil
NA
Organ rejection (immunosuppressants)
Influenza virus
A/Puerto Rico/8/34
Pathway
MTT assay
Decrease (50 %)
Approved, Investigational
31941776
DrugRepV_7933Mycophenolic acid
Antineoplastic and Immunomodulating Agents
Organ rejection (immunosuppressants)
Influenza virus
A/Puerto Rico/8/34
Pathway
MTT assay
Decrease (50 %)
Approved
31941776
DrugRepV_7934Antimycin A
NA
NA
Influenza virus
A/New Caledonia/20/1999
Pathway
MTT assay
Decrease (50 %)
NA
31941776
DrugRepV_7935Brequinar
NA
NA
Influenza virus
A/New Caledonia/20/1999
Pathway
MTT assay
Decrease (50 %)
Experimental
31941776
DrugRepV_79366-Azauridine
NA
Cancer
Influenza virus
A/New Caledonia/20/1999
Pathway
MTT assay
Decrease (50 %)
NA
31941776
DrugRepV_7937Azaribine
NA
Psoriasis
Influenza virus
A/New Caledonia/20/1999
Pathway
MTT assay
Decrease (50 %)
NA
31941776
DrugRepV_7938Pyrazofurin
NA
NA
Influenza virus
A/New Caledonia/20/1999
Pathway
MTT assay
Decrease (50 %)
NA
31941776
DrugRepV_7939AVN-944
NA
Cancer
Influenza virus
A/New Caledonia/20/1999
Pathway
MTT assay
Decrease (50 %)
Investigational
31941776
DrugRepV_7940Mycophenolate mofetil
NA
Organ rejection (immunosuppressants)
Influenza virus
A/New Caledonia/20/1999
Pathway
MTT assay
Decrease (50 %)
Approved, Investigational
31941776
DrugRepV_7941Mycophenolic acid
Antineoplastic and Immunomodulating Agents
Organ rejection (immunosuppressants)
Influenza virus
A/New Caledonia/20/1999
Pathway
MTT assay
Decrease (50 %)
Approved
31941776
DrugRepV_8277Asunaprevir
Antiinfectives For Systemic Use
Hepatitis C virus
Zika virus
NA
NA
MTT assay
Decrease (50 %)
Phase III
32488021
DrugRepV_8278Simeprevir
Antiinfectives For Systemic Use
Hepatitis C virus
Zika virus
NA
NA
MTT assay
Decrease (50 %)
Approved
32488021
DrugRepV_8339((4-((3-fluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8340((4-((2,3-difluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8341((4-((3,3-difluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_83424-((4-((2,3-difluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8343((4-((3-fluoro-2-methyl-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8344((4-((3-fluoro-3-methyl-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8345((4-((3-fluoro-4-methyl-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8346((4-((3-fluoro-2-methoxy-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8347((4-((3-fluoro-3-methoxy-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8348((4-((3-fluoro-4-methoxy-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino) benzonitrile
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8349((4-((2-chloro-3-fluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino) benzonitrile
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8350((4-((4-chloro-3-fluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8351((4-((3-fluoro-2-(trifluoromethyl)-[1,1-biphenyl]-4-yl)(hydroxylimino)methyl)pyrimidin-2-yl) amino)benzonitrile
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8352((4-((3-fluoro-4-(trifluoromethyl)-[1,1-biphenyl]-4-yl)(hydroxylimino)methyl)pyrimidin-2-yl) amino)benzonitrile
NA
NA
Human immunodeficiency virus
IIIB
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8353((4-((3-fluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
E138K
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8354((4-((2,3-difluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
E138K
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8355((4-((3,3-difluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
E138K
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_83564-((4-((2,3-difluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
E138K
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8357((4-((3-fluoro-2-methyl-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
E138K
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8358((4-((3-fluoro-3-methyl-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
E138K
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8359((4-((3-fluoro-4-methyl-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
E138K
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8360((4-((3-fluoro-2-methoxy-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
E138K
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8361((4-((3-fluoro-3-methoxy-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
E138K
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8362((4-((3-fluoro-4-methoxy-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino) benzonitrile
NA
NA
Human immunodeficiency virus
E138K
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8363((4-((2-chloro-3-fluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino) benzonitrile
NA
NA
Human immunodeficiency virus
E138K
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8364((4-((4-chloro-3-fluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
E138K
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8365((4-((3-fluoro-2-(trifluoromethyl)-[1,1-biphenyl]-4-yl)(hydroxylimino)methyl)pyrimidin-2-yl) amino)benzonitrile
NA
NA
Human immunodeficiency virus
E138K
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8366((4-((3-fluoro-4-(trifluoromethyl)-[1,1-biphenyl]-4-yl)(hydroxylimino)methyl)pyrimidin-2-yl) amino)benzonitrile
NA
NA
Human immunodeficiency virus
E138K
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8367((4-((3-fluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
L100I
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8368((4-((2,3-difluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
L100I
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8369((4-((3,3-difluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
L100I
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_83704-((4-((2,3-difluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
L100I
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8371((4-((3-fluoro-2-methyl-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
L100I
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8372((4-((3-fluoro-3-methyl-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
L100I
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8373((4-((3-fluoro-4-methyl-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
L100I
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8374((4-((3-fluoro-2-methoxy-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
L100I
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8375((4-((3-fluoro-3-methoxy-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
L100I
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8376((4-((3-fluoro-4-methoxy-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino) benzonitrile
NA
NA
Human immunodeficiency virus
L100I
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8377((4-((2-chloro-3-fluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino) benzonitrile
NA
NA
Human immunodeficiency virus
L100I
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8378((4-((4-chloro-3-fluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
L100I
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8379((4-((3-fluoro-2-(trifluoromethyl)-[1,1-biphenyl]-4-yl)(hydroxylimino)methyl)pyrimidin-2-yl) amino)benzonitrile
NA
NA
Human immunodeficiency virus
L100I
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8380((4-((3-fluoro-4-(trifluoromethyl)-[1,1-biphenyl]-4-yl)(hydroxylimino)methyl)pyrimidin-2-yl) amino)benzonitrile
NA
NA
Human immunodeficiency virus
L100I
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8381((4-((3-fluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
K103N
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8382((4-((2,3-difluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
K103N
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8383((4-((3,3-difluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
K103N
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_83844-((4-((2,3-difluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
K103N
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8385((4-((3-fluoro-2-methyl-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
K103N
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8386((4-((3-fluoro-3-methyl-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
K103N
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8387((4-((3-fluoro-4-methyl-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
K103N
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8388((4-((3-fluoro-2-methoxy-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
K103N
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8389((4-((3-fluoro-3-methoxy-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
K103N
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8390((4-((3-fluoro-4-methoxy-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino) benzonitrile
NA
NA
Human immunodeficiency virus
K103N
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8391((4-((2-chloro-3-fluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino) benzonitrile
NA
NA
Human immunodeficiency virus
K103N
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8392((4-((4-chloro-3-fluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
K103N
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8393((4-((3-fluoro-2-(trifluoromethyl)-[1,1-biphenyl]-4-yl)(hydroxylimino)methyl)pyrimidin-2-yl) amino)benzonitrile
NA
NA
Human immunodeficiency virus
K103N
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8394((4-((3-fluoro-4-(trifluoromethyl)-[1,1-biphenyl]-4-yl)(hydroxylimino)methyl)pyrimidin-2-yl) amino)benzonitrile
NA
NA
Human immunodeficiency virus
K103N
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8395((4-((3-fluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
Y181C
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8396((4-((2,3-difluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
Y181C
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8397((4-((3,3-difluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
Y181C
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_83984-((4-((2,3-difluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
Y181C
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8399((4-((3-fluoro-2-methyl-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
Y181C
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8400((4-((3-fluoro-3-methyl-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
Y181C
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8401((4-((3-fluoro-4-methyl-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
Y181C
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8402((4-((3-fluoro-2-methoxy-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
Y181C
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8403((4-((3-fluoro-3-methoxy-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
Y181C
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8404((4-((3-fluoro-4-methoxy-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino) benzonitrile
NA
NA
Human immunodeficiency virus
Y181C
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8405((4-((2-chloro-3-fluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino) benzonitrile
NA
NA
Human immunodeficiency virus
Y181C
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8406((4-((4-chloro-3-fluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
Y181C
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8407((4-((3-fluoro-2-(trifluoromethyl)-[1,1-biphenyl]-4-yl)(hydroxylimino)methyl)pyrimidin-2-yl) amino)benzonitrile
NA
NA
Human immunodeficiency virus
Y181C
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8408((4-((3-fluoro-4-(trifluoromethyl)-[1,1-biphenyl]-4-yl)(hydroxylimino)methyl)pyrimidin-2-yl) amino)benzonitrile
NA
NA
Human immunodeficiency virus
Y181C
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8409((4-((3-fluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
Y188L
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8410((4-((2,3-difluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
Y188L
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8411((4-((3,3-difluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
Y188L
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_84124-((4-((2,3-difluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
Y188L
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8413((4-((3-fluoro-2-methyl-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
Y188L
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8414((4-((3-fluoro-3-methyl-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
Y188L
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8415((4-((3-fluoro-4-methyl-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
Y188L
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8416((4-((3-fluoro-2-methoxy-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
Y188L
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8417((4-((3-fluoro-3-methoxy-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
Y188L
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8418((4-((3-fluoro-4-methoxy-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino) benzonitrile
NA
NA
Human immunodeficiency virus
Y188L
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8419((4-((2-chloro-3-fluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino) benzonitrile
NA
NA
Human immunodeficiency virus
Y188L
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8420((4-((4-chloro-3-fluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
Y188L
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8421((4-((3-fluoro-2-(trifluoromethyl)-[1,1-biphenyl]-4-yl)(hydroxylimino)methyl)pyrimidin-2-yl) amino)benzonitrile
NA
NA
Human immunodeficiency virus
Y188L
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8422((4-((3-fluoro-4-(trifluoromethyl)-[1,1-biphenyl]-4-yl)(hydroxylimino)methyl)pyrimidin-2-yl) amino)benzonitrile
NA
NA
Human immunodeficiency virus
Y188L
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8423((4-((3-fluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
F227L + V106A
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8424((4-((2,3-difluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
F227L + V106A
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8425((4-((3,3-difluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
F227L + V106A
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_84264-((4-((2,3-difluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
F227L + V106A
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8427((4-((3-fluoro-2-methyl-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
F227L + V106A
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8428((4-((3-fluoro-3-methyl-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
F227L + V106A
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8429((4-((3-fluoro-4-methyl-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
F227L + V106A
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8430((4-((3-fluoro-2-methoxy-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
F227L + V106A
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8431((4-((3-fluoro-3-methoxy-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
F227L + V106A
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8432((4-((3-fluoro-4-methoxy-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino) benzonitrile
NA
NA
Human immunodeficiency virus
F227L + V106A
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8433((4-((2-chloro-3-fluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino) benzonitrile
NA
NA
Human immunodeficiency virus
F227L + V106A
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8434((4-((4-chloro-3-fluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
F227L + V106A
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8435((4-((3-fluoro-2-(trifluoromethyl)-[1,1-biphenyl]-4-yl)(hydroxylimino)methyl)pyrimidin-2-yl) amino)benzonitrile
NA
NA
Human immunodeficiency virus
F227L + V106A
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8436((4-((3-fluoro-4-(trifluoromethyl)-[1,1-biphenyl]-4-yl)(hydroxylimino)methyl)pyrimidin-2-yl) amino)benzonitrile
NA
NA
Human immunodeficiency virus
F227L + V106A
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8437((4-((3-fluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
RES056
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8438((4-((2,3-difluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
RES056
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8439((4-((3,3-difluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
RES056
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_84404-((4-((2,3-difluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
RES056
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8441((4-((3-fluoro-2-methyl-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
RES056
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8442((4-((3-fluoro-3-methyl-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
RES056
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8443((4-((3-fluoro-4-methyl-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
RES056
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8444((4-((3-fluoro-2-methoxy-[1,1-biphenyl]-4-yl)(hydroxyimino) methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
RES056
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8445((4-((3-fluoro-3-methoxy-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
RES056
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8446((4-((3-fluoro-4-methoxy-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino) benzonitrile
NA
NA
Human immunodeficiency virus
RES056
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8447((4-((2-chloro-3-fluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino) benzonitrile
NA
NA
Human immunodeficiency virus
RES056
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8448((4-((4-chloro-3-fluoro-[1,1-biphenyl]-4-yl)(hydroxyimino)methyl)pyrimidin-2-yl)amino)benzonitrile
NA
NA
Human immunodeficiency virus
RES056
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8449((4-((3-fluoro-2-(trifluoromethyl)-[1,1-biphenyl]-4-yl)(hydroxylimino)methyl)pyrimidin-2-yl) amino)benzonitrile
NA
NA
Human immunodeficiency virus
RES056
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8450((4-((3-fluoro-4-(trifluoromethyl)-[1,1-biphenyl]-4-yl)(hydroxylimino)methyl)pyrimidin-2-yl) amino)benzonitrile
NA
NA
Human immunodeficiency virus
RES056
Pathway
MTT assay
Decrease (50 %)
NA
32334191
DrugRepV_8452Itraconazole
Antiinfectives For Systemic Use
Fungal infections (Pulmonary and extrapulmonary blastomycosis, Histoplasmosis, Aspergillosis, and Onychomycosis)
Influenza virus
PR8M
Pathway
MTT assay
Decrease (50 %)
Approved, Investigational
30866762
DrugRepV_8453Itraconazole
Antiinfectives For Systemic Use
Fungal infections (Pulmonary and extrapulmonary blastomycosis, Histoplasmosis, Aspergillosis, and Onychomycosis)
Influenza virus
PR8M
Pathway
MTT assay
Decrease (90 %)
Approved, Investigational
30866762
DrugRepV_8454Posaconazole
Antiinfectives For Systemic Use
Fungal infections (Aspergillus and Candida infections)
Influenza virus
PR8M
Pathway
MTT assay
Decrease (50 %)
Approved, Investigational, Vet approved
30866762
DrugRepV_8455Posaconazole
Antiinfectives For Systemic Use
Fungal infections (Aspergillus and Candida infections)
Influenza virus
PR8M
Pathway
MTT assay
Decrease (90 %)
Approved, Investigational, Vet approved
30866762